Severe hypokalaemia with paralysis induced by small doses of liquorice.

نویسندگان

  • A M Cumming
  • K Boddy
  • J J Brown
  • R Fraser
  • A F Lever
  • P L Padfield
  • J I Robertson
چکیده

A patient, who presented with a flaccid quadriplegia due to profound hypokalaemia, is described. Hypokalaemia and myoglobinuria were caused by the ingestion of small amounts of liquorice contained in a laxative preparation. Subsequent controlled administration of small amounts of this preparation induced marked hypokalaemia. This was associated with sodium retention and potassium loss confirming a mineralocorticoid-like action. The sodium retention was associated with suppression of plasma levels of renin and aldosterone.

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منابع مشابه

Low-dose liquorice ingestion resulting in severe hypokalaemic paraparesis, rhabdomyolysis and nephrogenic diabetes insipidus

In daily practice hypokalaemia is frequently observed. It can be accompanied by various adverse events and can even be life threatening. Frequent causes are intestinal and urinary loss, i.e. diarrhoea or use of diuretics. Glycyrrhizin-containing substances, such as liquorice, are a well-known but rare cause of hypokalaemia. They can induce an apparent mineralocorticoid excess-like syndrome, oft...

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Total body potassium depletion and severe myopathy due to chronic liquorice ingestion.

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Severe hypokalaemic paralysis and rhabdomyolysis due to ingestion of liquorice.

Chronic ingestion of liquorice induces a syndrome with findings similar to those in primary hyperaldosteronism. We describe a patient who, with a plasma K+ of 1.8 mmol/l, showed a paralysis and severe rhabdomyolysis after the habitual consumption of natural liquorice. Liquorice has become widely available as a flavouring agent in foods and drugs. It is important for physicians to keep liquorice...

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Liquorice: a root cause of secondary hypertension

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عنوان ژورنال:
  • Postgraduate medical journal

دوره 56 657  شماره 

صفحات  -

تاریخ انتشار 1980